[Spm] Force of Adhesion Variations

[Aubrey, Clare E]

Our biggest problem is when we measure forces in liquid with one tip and then when a different tip is tried the forces can be two, three, or four times larger or smaller than the initial measurements.  Each time we are using brand new tips from the same wafer.  We are also using clean new surfaces.  We are also very careful in controlling the environment and purity of the solvent.  What can we do to minimize this discrepancy between tips?
 
Thanks
 
Clare Aubrey Medendorp
University of Kentucky
Pharmaceutical Sciences
ceaubr2 at email.uky.edu